Two publications of researchers at the Flanders Institute of Biotechnology (VIB) with Lipotype lipidomics

Lipotype Shotgun Lipidomics coupled with the novel superparamagnetic nanoparticles-based organelle purification uncovers lipid composition of plasma membrane and endosomes in storage disorder diseases.


A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency – Scientific Reports, 2017
Arun K. Tharkeshwar, Jesse Trekker, Wendy Vermeire, Jarne Pauwels, Ragna Sannerud, David A. Priestman, Danielle te Vruchte, Katlijn Vints, Pieter Baatsen, Jean-Paul Decuypere, Huiqi Lu, Shaun Martin, Peter Vangheluwe, Johannes V. Swinnen, Liesbet Lagae, Francis Impens, Frances M. Platt, Kris Gevaert, Wim Annaert 


Lipotype Shotgun Lipidomics applied to mitochondria helps to link the lipid metabolism with the electron transport via action of phosphatase and tensin homologue–induced kinase (PINK1), a protein associated with Parkinson’s disease.

Cardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiency – The Journal of Cell Biology, 2017
Melissa Vos, Ann Geens, Claudia Böhm, Liesbeth Deaulmerie, Jef Swerts, Matteo RossiKatleen Craessaerts, Elvira P. Leites, Philip Seibler, Aleksandar Rakovic, Thora Lohnau, Bart De Strooper, Sarah-Maria Fendt, Vanessa A. Morais, Christine Klein, Patrik Verstreken


Read more about research at VIB: http://www.vib.be

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