CASE STUDY

Lipid changes in Arabidopis thaliana mitochondria

University of Wroclaw
Hanna Janska Lab

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The laboratory of professor Hanna Janska at the Faculty of Biotechnology, University of Wroclaw focuses on the role of mitochondria in plant stress responses. The Janska Lab has scrutinized the role of FTSH4 – one of the metalloproteases in mitochondria of Arabidopsis thaliana, a model plant. This protein suppresses oxidative damage of mitochondrial proteins by the indirect control of cardiolipin abundance. Lipotype delivered detailed, quantitative information on lipid composition of mitochondria purified from ftsh4 mutant and healthy plants, which helped to pinpoint the role of cardiolipin in the FTSH4 functionality. The collaboration between the Janska Lab and Lipotype demonstrates the power of lipid analysis in analyzing molecular processes occurring in organelles.
About the Hanna Janska Lab at Faculty of Biotechnology, the University of Wroclaw

The Hanna Janska laboratory is focused on the role of mitochondria in plant development and stress response, and also in mitochondrial protein quality control system and regulation of the mitochondrial genes translation.

Reference

Lack of FTSH4 protease affects protein carbonylation, mitochondrial morphology and phospholipid content in mitochondria of Arabidopsis: new insights into a complex interplay – Plant Physiology, June 13, 2016

Elwira Smakowska, Renata Skibior Blaszczyk, Malgorzata Czarna, Marta Kolodziejczak, Malgorzata Kwasniak Owczarek, Katarzyna Parys, Christiane Funk, Hanna Janska